• Understanding the psychological experiences of loneliness in later life: qualitative protocol to inform technology development

    Objectives Loneliness is a public health issue impacting the health and well-being of older adults. This protocol focuses on understanding the psychological experiences of loneliness in later life to inform technology development as part of the ‘Design for health ageing: a smart system to detect loneliness in older people’ (DELONELINESS) study. Methods and analysis Data will be collected from semi-structured interviews with up to 60 people over the age of 65 on their experiences of loneliness and preferences for sensor-based technologies. The interviews will be audio-recorded, transcribed and analysed using a thematic codebook approach on NVivo software. Ethics and dissemination This study has received ethical approval by Research Ethics Committee’s at King’s College London (reference number: LRS/DP-21/22-33376) and the University of Sussex (reference number: ER/JH878/1). All participants will be required to provide informed consent. Results will be used to inform technology development within the DELONELINESS study and will be disseminated in peer-reviewed publications and conferences.

    Jessica Rees, Wei Liu, Sebastien Ourselin, Yu Shi, Freya Probst, Michela Antonelli, Anthea Tinker, Faith Matcham·2023·BMJ Open
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  • Digital self-report instruments for repeated measurement of mental health in the general adult population: a protocol for a systematic review

    stage 1

    Introduction Digital technologies present tremendous opportunities for enabling long-term measurement of mental health in the general population. Emerging studies have established preliminary efficacy of collecting self-report data digitally. However, a key challenge when developing a new self-report instrument is navigating the abundance of existing instruments to select relevant constructs for measurements. This review is a precursor to developing a novel future integrated digital instrument for repeated measurements. We interrogate the literature as the first step towards optimal measurement of the multifaceted mental health concept, in the context of digital repeated measurement. This review aims to identify (1) digital self-report instruments administered repeatedly to measure the mental health of the general adult population; (2) their structure and format; (3) their psychometric properties; (4) their usage in empirical studies; and (5) the constructs these instruments were designed to measure (as characterised in the original publication), and the constructs the instruments have been used to measure in the identified empirical studies. Methods and analysis Five major electronic databases will be searched. Studies administering mental health instruments (in English) repeatedly to community dwellers in the general adult population are eligible. A reviewer will preliminarily screen for eligible studies. Then, two reviewers will independently screen the full text of the eligible articles and extract data. Both reviewers will resolve any disagreement through discussion or with a third reviewer. After the data extraction, a reviewer will manually search for the structure, format, psychometric properties and the original constructs these instruments were developed to measure. This review will synthesise the results in a narrative approach. The reporting in this review will be guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Ethics and dissemination Ethical approval is not required as no data will be collected. Findings of the systematic review will be disseminated through peer-reviewed publications and conference presentations. PROSPERO registration number CRD42022306547

    Zhao Hui Koh, Jason Skues, Greg Murray·2023·BMJ Open
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  • Opto nongenetics inhibition of neuronal firing

    stage 1

    Abstract Optogenetics is based on the selective expression of exogenous opsins by neurons allowing experimental control of their electrical activity using visible light. The interpretation of the results of optogenetic experiments is based on the assumption that light stimulation selectively acts on those neurons expressing the exogenous opsins without perturbing the activity of naive ones. Here, we report that light stimulation, of wavelengths and power in the range of those normally used in optogenetic experiments, consistently reduces the firing activity of naive Mitral Cells ( MC s) and Tufted Neurons in the olfactory bulb as well as in Medium Spiny Neurons ( MSN s) in the striatum. No such effect was observed for cerebellar Purkinje and hippocampal CA 1 neurons. The effects on MC firing appear to be mainly due to a light‐induced increase in tissue temperature, between 0.1 and 0.4°C, associated with the generation of a hyperpolarizing current and a modification of action potential ( AP ) shape. Therefore, light in the visible range can affect neuronal physiology in a cell‐specific manner. Beside the implications for optogenetic studies, our results pave the way to investigating the use of visible light for therapeutic purposes in pathologies associated with neuronal hyperexcitability.

    Karima Ait Ouares, Corinne Beurrier, Marco Canepari, Gwenaelle Laverne, Nicola Kuczewski·2019·European Journal of Neuroscience
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  • Corporate Scandals and Regulation

    stage 2

    Are regulatory interventions delayed reactions to market failures or can regulators proactively pre-empt corporate misbehavior? From a public interest view, we would expect “effective” regulation to ex ante mitigate agency conflicts between corporate insiders and outsiders, and prevent corporate misbehavior from occurring or quickly rectify transgressions. However, regulators are also self-interested and may be captured, uninformed, or ideological, and become less effective as a result. In this registered report, we develop a historical time series of corporate (accounting) scandals and (accounting) regulations for a panel of 26 countries from 1800 to 2015. An analysis of the lead-lag relations at both the global and individual country level yields the following insights: (1) Corporate scandals are an antecedent to regulation over long stretches of time, suggesting that regulators are typically less flexible and informed than firms. (2) Regulation is positively related to the incidence of future scandals, suggesting that regulators are not fully effective, that explicit rules are required to identify scandalous corporate actions, or that new regulations have unintended consequences. (3) There exist systematic differences in these lead-lag relations across countries and over time, suggesting that the effectiveness of regulation is shaped by fundamental country characteristics like market development and legal tradition.

    Luzi Hail, Ahmed Tahoun, Clare Wang·2018·Journal of Accounting Research
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  • Problematic online sexual activities in men: The role of self-esteem, loneliness, and social anxiety

    stage 2

    Several studies have shown that problematic use of online sexual activities (OSAs) can constitute a dysfunctional coping strategy that reflects a compensatory usage of the Internet. Yet, some specific risk factors—widely investigated in the field of general problematic Internet use—have to date been scarcely studied within the context of OSA. Hence, the goal of this study was to test a theoretical model in which self-esteem, loneliness, and social anxiety are hypothesized to predict the type of OSAs favored and their potential addictive use. To this end, an online survey was conducted in a sample of self-selected men who used OSAs on a regular basis (N = 209). Results showed that low self-esteem is positively associated with loneliness and high social anxiety, which were in turn positively related to involvement in two specific OSAs: use of pornography and the search for online sexual contacts. Higher engagement in these OSA activities was related to symptoms of addictive usage. These findings underline the importance in psychological interventions of taking into account the specific OSA practiced to improve self-esteem and to reduce loneliness and symptoms of social anxiety.

    Aline Wéry, Natale Canale, Caroline Bell, Benoit Duvivier, Joël Billieux·2020·Human Behavior and Emerging Technologies
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  • Different path to happiness: The role of basic psychological need satisfaction in benefiting close and distant others

    Numerous studies show that prosocial behavior leads to positive emotional outcomes for the actor, yet does it matter, who the beneficiary is? The present paper explores differential effects of helping acts towards close versus distant recipients on subjective well-being and the role that basic psychological needs play in this relationship. Two studies using event-recall (N = 127) and interventional (N = 305) designs in Russian samples were conducted to test our hypotheses. Study 1 showed that performing acts of kindness towards family and friends (compared to a control condition) led to higher satisfaction of the needs for relatedness and morality, while helping strangers increased only the latter. Study 2 failed to unconditionally replicate the prosocial-happiness link; however, when the need for competence was controlled for, helping both types of recipients was shown to provide higher event-level well-being outcomes. The positive effect of prosocial acts toward strong ties was mediated by relatedness and morality satisfaction, while when the recipient was a stranger, the effect was accounted for by fulfilling the needs for morality and autonomy. No significant event-level well-being differences were detected between those helping close versus distant others and no differences in positive affect, negative affect or life satisfaction emerged between the three conditions. The paper provides support for the importance of the self-perceived impact for the success of kindness interventions. We conclude with a discussion of implications for kindness interventions towards different recipients.

    Ekaterina Nastina, Inna F Deviatko·2023·Journal of Social and Personal Relationships
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  • A Registered Report on Place-Based Resentment: Exploring Urban-Rural Tensions in Sweden

    This Registered Report examines urban-rural tensions in Sweden – a historically egalitarian, multi-party welfare state with strong geographical equalization schemes, making it a least-likely case for place-based resentment theories. Using an online survey experiment (n = 2,051), we measured resentment through perceptions of in-group and out-group, and by experimentally varying whether political statements came from rural or urban politicians. Rural respondents showed stronger in-group identification, greater place-based resentment, and more negative stereotypes of their out-group than urban respondents. However, we find no evidence of place-based bias – that is, that rural respondents are less receptive to urban politicians’ statements, or vice versa. These findings reveal clear urban-rural tensions in a context often considered unlikely for such divides, underscoring the role of regional identities in political discourse and policy in multi-party welfare states beyond Anglo-Saxon settings, while indicating that these tensions do not translate into systematic bias in evaluating political statements.

    Kajsa Hansson, Gissur Erlingsson, Gustav Tinghög·2025·Journal of Experimental Political Science
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  • Illusory traits: Wrong but sometimes useful

    Psychological measures frequently show trait-like properties, and the ontological status of stable psychological traits has been discussed for decades. We argue that these properties can emerge from causal dynamics of time-varying processes, which are omitted from the analysis model, potentially leading to the estimation of traits that are, at least in part, illusory. Theories positing the importance of a large set of dynamic psychological causes across development are consistent with the existence of illusory traits. We show via simulation that even a linear system with many processes can generate a covariance matrix with trait-like properties. We then attempt to examine how illusory traits affect our conclusions drawn from a common statistical model, which assumes stable traits to analyze longitudinal panel data—a random-intercept cross-lagged panel model (RI-CLPM). We find that the RI-CLPM sometimes falsely detects the existence of traits in the presence of omitted processes, even when the data-generating model does not include any traits. However, in this scenario, the RI-CLPM estimates less causally biased autoregressive and cross-lagged effects than an analysis model, which does not assume traits (i.e., the cross-lagged panel model). The results indicate that the detection of trait variance should not be inferred as strong evidence for the existence of time-invariant trait causes. On the other hand, even when traits are illusory, statistical models assuming stable traits may sometimes be useful for causal inference. (PsycInfo Database Record (c) 2026 APA, all rights reserved)

    Drew H. Bailey, Nicolas Hübner, Steffen Zitzmann, Martin Hecht, Kou Murayama·2026
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  • Behavioral detection of emotional, high-stakes deception: Replication in a registered report

    stage 2

    Objective: We replicated research by ten Brinke and Porter (2012), who reported that a combination of four behavioral cues (word count, tentative words, upper face surprise, lower face happiness) could accurately discriminate deceptive murderers from genuinely distressed individuals, pleading for the return of a missing relative. Hypotheses: We hypothesized that each of the four behavioral cues identified in the original study would be similarly related (i.e., size, direction, significance) to veracity in a novel set of pleaders. With these cues as predictors, we also hypothesized that logistic regression models—separately testing the original and replication samples—would produce similar accuracy rates exceeding chance in discriminating genuine from deceptive pleaders. Method: We gathered a new sample of public appeals, including 82 genuine and 14 deceptive pleaders. After establishing ground truth, we transcribed video-recorded pleas and coded them for the presence of upper face surprise and lower face happiness. We used Linguistic Inquiry and Word Count to determine word count and the proportion of tentative words in each appeal. Results: We found support for several hypotheses. Tentative words were used significantly more by deceptive (vs. genuine) pleaders in both the original and replication samples. Deceptive pleaders used significantly fewer words in both samples, although this relationship was significant only in the original sample. Liars in both samples smiled more than truth-tellers, although this relationship was statistically significant only in the replication sample. However, predictive accuracy was poor and did not differ from chance in the replication sample. Conclusions: Findings do not provide a tidy picture of the reliability of behavioral cues to deception. Although some behavioral cues did replicate across samples, others did not. More research will be necessary to understand the factors that produce variable findings across samples, despite using the same methods of investigation. (PsycInfo Database Record (c) 2025 APA, all rights reserved)

    Leanne ten Brinke, Samantha Sprigings, Cameo Brown, Chloe Kam, Hugues Delmas·2025·Law and Human Behavior
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  • The P600 as a correlate of ventral attention network reorientation

    When, during language processing, a reader or listener is confronted with a structurally deviant phrase, this typically elicits a late positive ERP deflection (P600). The P600 is often understood as a correlate of structural analysis. This assumption has informed a number of neurocognitive models of language. However, the P600 strongly resembles the P3, likely a more general electrophysiological correlate of reorientation behaviour supported by noradrenergic input to the ventral attention network/VAN. Some researchers have proposed that the P600 is an instance of the P3, not a distinct component reflecting the analysis of structured inputs. Here, we tested the P600-as-P3 hypothesis by estimating the alignment of the P600 elicited in a visual sentence processing task to simultaneously collected behavioural measures. A similar analysis was undertaken for a P3 elicited in a separate non-linguistic (face detection) task. Since the P3 is usually aligned to reaction time/RT, the same should hold for the P600; a failure to find RT alignment of the P600 would pose a problem for the P600-as-P3 hypothesis. In contrast, RT alignment of the P600 would associate it with the well-established VAN/Locus Coeruleus – Noradrenaline – Network subserving cortical reorientation. We failed to falsify the hypothesis of RT alignment. Secondary measures, while less unambiguous, were more in agreement with the P600-as-P3 hypothesis. We interpret our results as corroborating the hypothesis that the P600 is a P3, in that it shows that the P600 is RT-aligned. This perspective is unpredicted by an account of the P600 as indexing high-level processing.

    Jona Sassenhagen, Ina Bornkessel-Schlesewsky·2015·Cortex
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  • Representing the location of manipulable objects in shape-selective occipitotemporal cortex: Beyond retinotopic reference frames?

    When interacting with objects, we have to represent their location relative to our bodies. To facilitate bodily reactions, location may be encoded in the brain not just with respect to the retina (retinotopic reference frame), but also in relation to the head, trunk or arm (collectively spatiotopic reference frames). While spatiotopic reference frames for location encoding can be found in brain areas for action planning, such as parietal areas, there is debate about the existence of spatiotopic reference frames in higher-level occipitotemporal visual areas. In an extensive multi-voxel pattern analysis (MVPA) fMRI study using faces, headless bodies and scenes stimuli, Golomb and Kanwisher (2012) did not find evidence for spatiotopic reference frames in shape-selective occipitotemporal cortex. This finding is important for theories of how stimulus location is encoded in the brain. It is possible, however, that their failure to find spatiotopic reference frames is related to their stimuli: we typically do not manipulate faces, headless bodies or scenes. It is plausible that we only represent body-centred location when viewing objects that are typically manipulated. Here, we tested for object location encoding in shape-selective occipitotemporal cortex using manipulable object stimuli (balls and cups) in a MVPA fMRI study. We employed Bayesian analyses to determine sample size and evaluate the sensitivity of our data to test the hypothesis that location can be encoded in a spatiotopic reference frame in shape-selective occipitotemporal cortex over the null hypothesis of no spatiotopic location encoding. We found strong evidence for retinotopic location encoding consistent with previous findings that retinotopic reference frames are common neural representations of object location. In contrast, when testing for spatiotopic encoding, we found evidence that object location information for small manipulable objects is not decodable in relation to the body in shape-selective occipitotemporal cortex. Post-hoc exploratory analyses suggested that spatiotopic aspects might modulate retinotopic location encoding. Overall, our findings provide evidence that there is no spatiotopic encoding that is independent of retinotopic location in shape-selective occipitotemporal cortex.

    Regine Zopf, Marina Butko, Alexandra Woolgar, Mark A. Williams, Anina N. Rich·2018·Cortex
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  • Mu suppression – A good measure of the human mirror neuron system?

    Mu suppression has been proposed as a signature of the activity of the human mirror neuron system (MNS). However the mu frequency band (8–13 Hz) overlaps with the alpha frequency band, which is sensitive to attentional fluctuation, and thus mu suppression could potentially be confounded by changes in attentional engagement. The specific baseline against which mu suppression is assessed may be crucial, yet there is little consistency in how this is defined. We examined mu suppression in 61 typical adults, the largest mu suppression study so far conducted. We compared different methods of baselining, and examined activity at central and occipital electrodes, to both biological (hands) and non-biological (kaleidoscope) moving stimuli, to investigate the involvement of attention and alpha activity in mu suppression. We also examined changes in beta power, another candidate index of MNS engagement. We observed strong mu suppression restricted to central electrodes when participants performed hand movements, demonstrating that mu is indeed responsive to the activity of the motor cortex. However, when we looked for a similar signature of mu suppression to passively observed stimuli, the baselining method proved to be crucial. Selective suppression for biological versus non-biological stimuli was seen at central electrodes only when we used a within-trial baseline based on a static stimulus: this method greatly reduced trial-by-trial variation in the suppression measure compared with baselines based on blank trials presented in separate blocks. Even in this optimal condition, 16–21% of participants showed no mu suppression. Changes in beta power also did not match our predicted pattern for MNS engagement, and did not seem to offer a better measure than mu. Our conclusions are in contrast to those of a recent meta-analysis, which concluded that mu suppression is a valid means to examine mirror neuron activity. We argue that mu suppression can be used to index the human MNS, but the effect is weak and unreliable and easily confounded with alpha suppression.

    Hannah M. Hobson, Dorothy V. M. Bishop·2016·Cortex
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  • Global network centrality of university rankings

    Universities and higher education institutions form an integral part of the national infrastructure and prestige. As academic research benefits increasingly from international exchange and cooperation, many universities have increased investment in improving and enabling their global connectivity. Yet, the relationship of university performance and its global physical connectedness has not been explored in detail. We conduct, to our knowledge, the first large-scale data-driven analysis into whether there is a correlation between university relative ranking performance and its global connectivity via the air transport network. The results show that local access to global hubs (as measured by air transport network betweenness) strongly and positively correlates with the ranking growth (statistical significance in different models ranges between 5% and 1% level). We also found that the local airport’s aggregate flight paths (degree) and capacity (weighted degree) has no effect on university ranking, further showing that global connectivity distance is more important than the capacity of flight connections. We also examined the effect of local city economic development as a confounding variable and no effect was observed suggesting that access to global transportation hubs outweighs economic performance as a determinant of university ranking. The impact of this research is that we have determined the importance of the centrality of global connectivity and, hence, established initial evidence for further exploring potential connections between university ranking and regional investment policies on improving global connectivity.

    Weisi Guo, Marco Del Vecchio, Ganna Pogrebna·2017·Royal Society Open Science
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  • Subliminal influence on preferences? A test of evaluative conditioning for brief visual conditioned stimuli using auditory unconditioned stimuli

    In the field of evaluative conditioning (EC), two opposing theories—propositional single-process theory versus dual-process theory—are currently being discussed in the literature. The present set of experiments test a crucial prediction to adjudicate between these two theories: Dual-process theory postulates that evaluative conditioning can occur without awareness of the contingency between conditioned stimulus (CS) and unconditioned stimulus (US); in contrast, single-process propositional theory postulates that EC requires CS-US contingency awareness. In a set of three studies, we experimentally manipulate contingency awareness by presenting the CSs very briefly, thereby rendering it unlikely to be processed consciously. We address potential issues with previous studies on EC with subliminal or near-threshold CSs that limited their interpretation. Across two experiments, we consistently found an EC effect for CSs presented for 1000 ms and consistently failed to find an EC effect for briefly presented CSs. In a third pre-registered experiment, we again found evidence for an EC effect with CSs presented for 1000 ms, and we found some indication for an EC effect for CSs presented for 20 ms.

    Tobias Heycke, Frederik Aust, Christoph Stahl·2017·Royal Society Open Science
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  • Probing the role of the vestibular system in motivation and reward-based attention

    The vestibular system has widespread connections in the central nervous system. Several activation loci following vestibular stimulations have been notably reported in deep, limbic areas that are otherwise difficult to reach and modulate in healthy subjects. Following preliminary evidence, suggesting that such stimulations might affect mood and affective processing, we wondered whether the vestibular system is also involved in motivation. Evolutionary accounts suggest that visuo-vestibular mismatches might have a role in preventing the search for and exploitation of goods that previously resulted in aversive reactions, as they would be a fine warning signal which follows the contact with or ingestion of noxious neurotoxins. The first question was thus whether vestibular stimulation alters sensitivity to reward. Secondly, we sought to assess whether attention is allocated in space differently when cued by highly motivational stimuli, and if this interplay is further modulated by the vestibular system. In order to evaluate both motivational and attentional assets, we administered a Posner-like cueing task to 30 healthy subjects concurrently receiving sham or galvanic vestibular stimulation (GVS; Left-Anodal and Right-Anodal configurations). The participants had to discriminate targets appearing in either exogenously cued or uncued locations (50% validity); cues predicted the amount of points (0, 2, or 10) and thus money that they could earn for a correct response. The results highlight a robust inhibition of return (IOR) (faster responses for invalidly-cued targets) which was not modulated by different levels of reward or GVS. Across all stimulation sessions, rewards exerted a powerful beneficial effect over performance: reaction times were faster when rewards were at stake. However, this effect was largest in sham, but greatly reduced in GVS conditions, most notably with the Right-Anodal configuration. This is the first evidence for a decreased sensitivity to rewards causally induced by a perturbation of the vestibular system. While future studies will shed light on its neural underpinnings and clinical implications, here we argue that GVS could be a safe and promising way to enrich our understanding of reward processes and eventually tackle the management of patients with aberrant sensitivity to rewards.

    Elvio Blini, Caroline Tilikete, Alessandro Farnè, Fadila Hadj-Bouziane·2018·Cortex
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  • Anticipating actions and corticospinal excitability: A preregistered motor TMS experiment

    Past research on action observation and imitation suggests that observing a movement activates a corresponding motor representation in the observer. However, recent research suggests that individuals may not only reflexively simulate the observed behavior but also simulate and engage in anticipated action without another person actually engaging in it. For example, it has been demonstrated that observing a triggering event (i.e., nose wrinkling) that potentially leads to the anticipation of an action (i.e., nose scratching) increases the likelihood that the observer will perform that action. In the present research, we applied motor Transcranial Magnetic Stimulation (TMS) to investigate such anticipated social action effects at the neurophysiological level within a trial-by-trial measure. While a pilot study suggests that observing nose wrinkling elicits stronger motor evoked potentials (MEPs) in participants' biceps muscles than observing control events, this effect could not be fully replicated in a preregistered study. Although a post hoc meta-analysis across both studies supports the general hypothesis, these results need to be taken cautiously. Implications of the results reported in the manuscript are discussed.

    Oliver Genschow, Lara Bardi, Marcel Brass·2018·Cortex
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  • Extending the limits of force endurance: Stimulation of the motor or the frontal cortex?

    Previous findings indicate that facilitation of primary motor cortex (PMC) activity using trans-cranial direct current stimulation (tDCS) could improve resistance to physical fatigue. However, studies have failed to consistently replicate these results. Using non-focal-tDCS during a fatiguing task, recent work showed no enhancement of corticospinal excitability of the PMC despite a longer endurance time and suggested that contamination in other brain regions involved in motor command may have occurred. In accordance with recent evidence supporting the role of the prefrontal cortex (PFC) in exercise maintenance, this double-blind sham-controlled crossover study (N = 22) compared the effect of high definition (HD)-tDCS of the PMC or the PFC on endurance time of a sustained contraction task of the elbow flexor. Brain activity was monitored using near infrared spectroscopy (NIRS) to measure the neurovascular response elicited by HD-tDCS. Electromyography (EMG) and force obtained during maximal voluntary and evoked contractions were assessed before and after the contraction task to explore the effect of brain stimulation on peripheral and central fatigue. While the stimulation affected the brain response in the PFC during the contraction task, no effects of the stimulation were observed on endurance time or fatigue indices. These results are discussed in relation to the neurocognitive models of physical effort.

    Rémi Radel, Gavin Tempest, Gauthier Denis, Pierre Besson, Raphael Zory·2017·Cortex
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  • Associations of fear, anger, happiness, and hope with risk judgments: Revisiting appraisal-tendency framework with a replication and extensions registered report of Lerner and Keltner (2001).

    Sirui Lu, Emir Efendić, Gilad Feldman·2025·Journal of Personality and Social Psychology
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  • Prior Knowledge and the Recall of Single Events and Instances of Repeated Events: A Registered Report

    Eva Rubínová, Heather L. Price, Sonja P. Brubacher·2025
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  • Antibiotic use and survival from breast cancer: A population-based cohort study in England and Wales

    The role of the gut microbiota in carcinogenesis is increasingly being acknowledged. Recent studies in multiple breast cancer mouse models have found that antibiotics, by altering the gut microbiota, can accelerate tumour growth. In humans, a recent cohort study restricted to triple negative breast cancer showed that breast cancer patients using a greater number of antibiotics had markedly worse survival. These studies have raised concerns about repeated antibiotic use in breast cancer patients. In this Registered Report, we investigated whether breast cancer patients using oral antibiotics had increased breast cancer-specific mortality. In population-based cohorts (n = 44,452), we did not observe a statistically significant association between antibiotic prescriptions after diagnosis and breast cancer-specific mortality (adjusted HR = 1.07 95% CI 0.87, 1.33) apart from prescriptions of 12 or more antibiotics (adjusted HR = 1.62 95% CI 1.31, 2.01). This association was weaker after adjustment for infections (adjusted HR = 1.44 95% 1.14, 1.81), when restricted to antibiotics within five years (adjusted HR = 1.33 95% 0.95, 1.84), and was similar for deaths from other causes (adjusted HR = 1.69 95% 1.19, 2.41). Frequent antibiotic users had higher cancer-specific mortality but the attenuation of associations in sensitivity analyses, and similar findings for other causes of death, suggest this increase may reflect residual confounding. Protocol registration: The Stage 1 protocol for this Registered Report was accepted in principle on 7 November 2023. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.24746721.v1.

    Chris R. Cardwell, Sarah M. Baxter, Andrew Jhl Snelling, Daniel Tzu-Hsuan Chen, Emma C. Atakpa, Úna McMenamin, Stuart A. McIntosh, Blánaid Hicks, Carol Ac Coupland, Aaron J. Brady, Finian J. Bannon, Julia Hippisley-Cox·2025·Nature Communications
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  • Stage 1 Registered Report: Testing the Causal Impact of Social Media Reduction Around the Globe

    Steve Rathje, Nejla Asimovic, Tiago Ventura, Sarah Mughal, Hannah Karsting, Claire Robertson, Christopher Barrie, Joshua A Tucker, Jay Joseph Van Bavel·2025
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  • Registered Report: A Replication Examining Occupational Experience and Performance on the Water-Level Task

    Elizabeth R. Tenney, Kylie Rochford, Amelia Stillwell, Coco Xinyue Liu, David Tannenbaum, Marie Hennecke, Jeanine K. Stefanucci, B. Ariel Blair, Jesse Graham, Bryan L. Bonner·2026·Psychological Science
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  • Higher Pitch, Slower Tempo, and Greater Stability in Singing than in Conversation among Mandarin speakers in Auckland: A Registered Report Replicating Ozaki et al. (2024)

    stage 2
    Zixuan Jia, Suzanne Purdy, Patrick E. Savage·2026
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  • Emotional Coherence under Hypoxia and Aging: A Registered Report on Subjective–Physiological Coupling

    stage 1
    Pierrick Laulan, Grégoire Millet, Ulrike Rimmele·2026·Psychophysiology
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  • Using Biometrics to Understand AI-Assisted Coding Performance and its Perception: a Registered Report

    stage 1
    Nadja Brix Koch, Theis Helth Stensgaard, Paolo Tell, Paolo Burelli, Guillaume Andrea Desaphy, Alberto Antonio Romano, Nicole Novielli, Fabio Calefato·2025
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  • Singing showed higher pitch, slower tempo and greater stability compared to conversation, and is associated with greater social bonding: A Registered Report replicating and extending Ozaki et al. (2024) with (NZ) English Speakers

    stage 2
    Zhuozhuang Shi, Zixuan Jia, Patrick E. Savage·2025
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  • Does oral breathing disrupt memory consolidation during waking rest? A registered report

    Bethanie Richards, Henning Holle, Shane Lindsay·2025·Quarterly Journal of Experimental Psychology
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  • An experimental investigation of daily mental contrasting with implementation intentions and goal motives in reducing bedtime procrastination: a registered report

    Objectives Mental contrasting with implementation intentions (MCII) is an effective self-regulation strategy for goal pursuit. Although it is a quick and cost-effective strategy, most of its applications have consisted of single-time training. Building on the existing research on bedtime procrastination, we propose that daily MCII applications can lead to more efficient pursuit of bedtime goals. Furthermore, we evaluate the conditions where MCII training could be more advantageous for people with different types of goal motives. Methods and Measures We recruited 297 participants via Prolific and randomly allocated participants into either daily MCII or single MCII groups for a week-long diary study. We measured goal motives, goal-regulatory variables, bedtime procrastination, and affect to test our hypotheses. We conducted a multilevel structural equation modelling using Mplus. Results Participants who completed MCII daily reported less bedtime procrastination than individuals who performed MCII one-off at the start of the week. Participants experienced increased positive affect and decreased negative affect when they procrastinated less. Autonomous goal motives were not associated with bedtime procrastination. Discussion Daily MCII appears as an effective and easy-to-implement strategy helps reducing bedtime procrastination. Future research should test the effectiveness of daily MCII in other contexts.

    Berke Sezer, Nikos Ntoumanis, Hugh Riddell, Daniel F. Gucciardi·2025·Psychology & Health
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  • Do buyback anomalies explain the stock return in Japan? A pre-registered report

    Over the past two decades, the number of stock buybacks by U.S. corporations has increased tremendously. While buyback anomalies have been investigated in the U.S., identifying whether they are also observable out of the U.S. markets, such as in Japan, is challenging yet necessary. This pre-registered report seeks to reveal whether buyback anomalies persist for longer periods in Japan's stock market. We focus on whether the “costly arbitrage view” supporting buyback anomalies in the U.S. market applies to the long-term buyback announcement returns in Japan's stock market. This study also focuses on whether bank ties in bank-based (financial) systems mitigate long-term excessive stock returns due to buyback anomalies. We shed light on regulatory discussions regarding the restriction of corporate buybacks. Our study contributes to determining whether bank monitoring is effective in mitigating the degree of buyback anomalies in bank-based systems.

    Hideaki Sakawa, Naoki Watanabel, Kenji Hiramatsu·2025·Pacific-Basin Finance Journal
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  • Development of arithmetic across the lifespan: A Registered Report

    Mine Avcil, Christina Artemenko·2023
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  • Are women really (not) more talkative than men? A registered report of binary gender similarities/differences in daily word use

    Colin Alexandr Tidwell, Alexander Francois Danvers, Valeria Pfeifer, David Sbarra, Matthias R. Mehl, Angelina J. Polsinelli, Charles L Raison, megan robbins, James Rilling, Richard B. Slatcher, Jessie Sun, Danielle B. Abel, Simine Vazire, Eva Alisic, ANDREW BEER, Sabrina Bierstetel, Kathryn Leigh Bollich-Ziegler, Michelle Bruni, William Calabrese, Christine Chiarello, Burcu Demiray, Sona Dimidjian, Karen Fingerman, Maximilian Haas, Deanna M Kaplan, Yijung Kim, Goran Knezevic, Ljiljana B. Lazarevic, Laura Luo, Alessandra Macbeth, Joseph H. Manson, Jennifer S Mascaro, Christina Metcalf, Kyle S. Minor, Suzanne A. Moseley, Mira Vasileva·2025
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  • Cortical markers of PAS-induced long-term potentiation and depression in the motor system: A TMS-EEG Registered Report

    Eleonora Arrigoni, Nadia Bolognini, Alberto Pisoni, Giacomo Guidali·2026·Imaging Neuroscience
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  • Do cynics lie to avoid exploitation, to exploit others, or not at all? A registered report on the relationship between cynicism and dishonesty

    Teodora Spiridonova, Margarita Leib, Ilja van Beest, Olga Stavrova·2025·European Journal of Personality
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  • Does blatantly contradictory information reduce the misinformation effect? A Registered Report replication of Loftus (1979)

    Rachel O'Donnell, Jason C. K. Chan·2023·Legal and Criminological Psychology
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  • A registered report on presentation factors that influence the attraction effect

    Context effects occur when the preference between two alternatives is affected by the presence of an extra alternative. These effects are some of the most well studied phenomena in multi-alternative, multi-attribute decision making. Recent research in this area has revealed an intriguing pattern of results. On the one hand, these effects are robust and ubiquitous. That is, they have been demonstrated in many domains and different choice settings. On the other hand, they are fragile and they disappear or even reverse under different conditions. This pattern of results has spurred debate and speculation about the cognitive mechanisms that drive these choices. The attraction effect, where the preference for an option increases in the presence of a dominated decoy, has generated the most controversy. In this registered report, we systematically vary factors that are known to be associated with the attraction effect to build a solid foundation of empirical results to aid future theory development. We find a robust attraction effect across the different conditions. The strength of this effect is modulated by the display order (e.g., decoy top, target middle, competitor bottom) and mode (numeric vs. graphical) but not display layout (by-attribute vs. by-alternative).

    Eeshan Hasan, Yanjun Liu, Nicole Owens, Jennifer S Trueblood·2023·OSF
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  • Effect of Traffic Separation and Nature Integration on Affect and Cerebral Oxygenation During Active Transport: An Immersive Virtual Reality and Multi-Study Design

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    Layan Fessler, Ségolène M. R. Guérin, Yvonne N. Delevoye-Turrell·2026·Zenodo
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  • Olfactory notes in the mind space

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    Michelle Caldana, Elena Rusconi·2026
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  • Revisiting the Combination of Static Analysis Error Traces and Dynamic Symbolic Execution: A Potential Approach for True Positive Confirmation (Registered Report)

    Yihua Xu, Chengyu Zhang, Geguang Pu·2025·Proceedings of the 34th ACM SIGSOFT International Symposium on Software Testing and Analysis
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  • Timbral cues underlie instrument-specific absolute pitch in expert oboists

    While absolute pitch (AP)—the ability to identify musical pitches without external reference—is rare even in professional musicians, anecdotal evidence and case-report data suggest that some musicians without traditional AP can nonetheless better name notes played on their musical instrument of expertise than notes played on instruments less familiar to them. We have called this gain in AP ability “instrument-specific absolute pitch” (ISAP). Here, we report the results of the first two experiments designed to investigate ISAP in professional oboists. In Experiment 1 (n = 40), superiority for identifying the pitch of oboe over piano tones varied along a continuum, with 37.5% of oboists demonstrating significant ISAP. Variance in accuracy across pitches was higher among ISAP-possessors than ISAP-non-possessors, suggestive of internalized timbral idiosyncrasies, and the use of timbral cues was the second-most commonly reported task strategy. For both timbres, both groups performed more accurately for pitches associated with white than black piano keys. In Experiment 2 (n = 12), oboists with ISAP were less accurate in pitch identification when oboe tones were artificially pitch-shifted. The use of timbral idiosyncrasies thus may constitute a widespread mechanism of ISAP. Motor interference, conversely, did not significantly reduce accuracy. This study offers the first evidence of ISAP among highly trained musicians and that reliance on subtle timbral (or intonational) idiosyncrasies may constitute an underlying mechanism of this ability in expert oboists. This provides a path forward for future studies extending the scientific understanding of ISAP to other instrument types, expertise levels, and musical contexts. More generally, this may deepen knowledge of specialized expertise, representing a range of implicit abilities that are not addressed directly in training, but which may develop through practice of a related skill set.

    Niels Chr Hansen, Lindsey Reymore·2024·PLOS ONE
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  • Empathic listening satisfies speakers' psychological needs and well-being, but doesn't directly deepen solitude experiences: A registered report

    A live discussion experiment was designed to test the effects of highly empathic (vs. moderately empathic) listening on solitude experiences. Participants were assigned to three conditions in which they: 1) Discussed a negative personal experience with a confederate (ostensibly another participant) exhibiting highly empathic listening; 2) Discussed an experience with a confederate exhibiting moderately empathic listening; or, 3) Engaged in a positive reframing exercise. Building on previous listening theory (Weinstein et al., 2022) and research (Itzchakov & Weinstein, 2021; Itzchakov, Weinstein, et al., 2022). We then assessed the two posited mechanisms of autonomy and relatedness and tested the expectations to be in solitude. All participants were instructed to spend ten minutes alone, phones off, and distractions stored away. While highly empathic listening enhanced participants' (i.e. speakers) autonomy and relatedness need satisfaction compared to the other two conditions and predicted initial increases in self- and social-connection, it did not subsequently improve solitude experiences, with no direct effects found predicting self-connection, peaceful affect, loneliness, or self-insight. Indirect effects linked empathic listening to self-connection and self-insight through autonomy satisfaction. While empathic listening fosters immediate psychological need satisfaction in social contexts, deeper listening interventions may be necessary to improve subsequent solitude periods.

    Netta Weinstein, Guy Itzchakov·2025·Journal of Experimental Social Psychology
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  • Weighing Down Thought: The Effect of Motor Disruption in Executive Function Tasks among Three-Year-Old Children

    This registered report examines the effect of motor disruption in the conscious control of behavior (i.e. executive function – EF) of three-year-old children in the Southern United States (N = 114). Specifically, we investigated how disrupting a relevant motor response influenced performance on two EF tasks. Each EF task had an initial phase intended to form a habit, and a switch phase that was the critical measure of EF. Children must inhibit the habit developed at the beginning of the task and reflect consciously on new demands. The multistep multilocation task examined the inhibition of a motor-based habit (response shift), while the Dimensional Change Card Sort examined the inhibition of a cognitive-based habit (attention shift). The motor disruption consisted of administering weighted armbands at two time points during the tasks (i.e. the beginning of the task or during switch trials only) to disrupt reaching behavior. Motor manipulation was found to have a differential effect on EF tasks among three-year-old children. While the armbands improved performance on the response shifting task relative to a no armband control condition, they did not significantly affect performance on the attention shifting task. Contrary to expectations, the armbands did not lead to more errors (habit disruption) during pre-switch trials in either task. These findings highlight the significance of considering both motor and cognitive factors in early childhood EF development. Further research is needed to explore the underlying mechanisms and implications of incorporating movement in EF development.

    Z. Reagan Pearce, Stephanie E. and Miller·2024·Journal of Cognition and Development
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  • It is not only <i>whether</i> I approach but also <i>why</i> I approach: A registered report on the role of action framing in approach/avoidance training effects

    Research on approach/avoidance training (AAT) effects shows that approach (i.e., reducing the distance between the self and a stimulus) leads to more positive evaluations of stimuli than avoidance (i.e., increasing the distance between the self and a stimulus). The present experiments relied on a grounded cognition approach to extend this finding by investigating the framing-dependency of AAT effects on facial representations of target stimuli. In a Preliminary Experiment, using antagonistic types of approach (affiliative vs. aggressive) and a reverse correlation paradigm, we found that approach led to more positive facial representations than avoidance when approach was portrayed as affiliative, but this effect decreased and tended to reverse (i.e., yielding more negative facial representations) when approach was portrayed as aggressive. Two registered experiments extended these results while also addressing important limitations of the Preliminary Experiment. First, to prevent any contrast emerging from the joint use of approach and avoidance, Experiment 1 isolated the unique effects of affiliative approach, aggressive approach, and avoidance compared to a control action. We also explored whether aggressive approach and avoidance (two negatively valenced yet distinct actions) produced negative effects characterized by divergent outcomes on facial features (e.g., weak vs. dominant). Second, Experiment 2 tested the importance of the experiential component of approach/avoidance actions by comparing the AAT with a mere instructions condition. Results of Experiments 1 and 2 proved consistent with a framing-dependency of AAT effects. Unveiling the framing-dependency of AAT effects challenges some of the current theoretical views on AAT effects.

    Marine Rougier, Mathias Schmitz, Ivane Nuel, Marie-Pierre Fayant, Baptiste Subra, Theodore Alexopoulos, Vincent Yzerbyt·2025·Journal of Experimental Social Psychology
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  • Examining the Structure of Personality Dysfunction Among Individuals Involved in Mental Health treatment: A Registered Report

    Personality dysfunction is a core element of the diagnosis of personality disorders in both main diagnostic systems (Diagnostic and Statistical Manual of Mental Disorders [5th ed.] Personality Disorders and ICD-11 [International Classification of Diseases, 11th Revision] Personality Disorders). A recent study by Sleep et al. explored the structure of personality dysfunction (N = 517 undergraduates) with exploratory bass-ackward factor analyses at the item level using items from six measures of personality functioning. The present study represents a replication of the study by Sleep and colleagues in a community sample of individuals currently in or seeking psychological/psychiatric treatment. Participants were recruited from Prolific who completed items from six measures of personality dysfunction (N = 457). The primary factor analysis identified three lower-order factors of impairment (Negative Self-Regard, Disagreeableness, and Intimacy Problems). These dysfunction factors showed moderate to strong relations to the factors generated by Sleep et al.; however, there were important differences in the overall structure suggesting a lack of formal replication.

    Ashmita Ghosh, Nathaniel L. Phillips, Chelsea E. Sleep, Donald R. Lynam, Joshua D. Miller·2025·Assessment
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  • Validity, Stability, and Change in Psychopathic Traits in Older Adults: A Registered Report

    Despite the importance of psychopathy—a construct with robust relations with externalizing outcomes—little is known about how psychopathic traits manifest in middle-age to older adulthood. In the present investigation, we used a large and diverse sample of older adults from the St. Louis Personality and Aging Network to examine psychopathy’s nomological network and whether these traits change over four time points spanning approximately 10 years. We also explored whether these changes were associated with changes in other important constructs (e.g., physical and psychological functioning) across the same time span. Psychopathy was operationalized in two ways: (a) via the factors of the triarchic psychopathy model, Meanness, Disinhibition, and Boldness, and (b) using a more macro approach via the Five-Factor Model Psychopathy Resemblance Index. We found that (a) the nomological network of psychopathy appears to be consistent with what has been observed in samples of younger adults, (b) psychopathic traits remain stable over time as adults make the transition from midlife to later life, and (c) changes that were observed are significantly related to changes in several important outcomes, including physical health, mental health, relationship satisfaction, intimate-partner aggression, and social functioning.

    Leigha Rose, Nathan T. Carter, Donald R. Lynam, Joshua D. Miller, Thomas F. Oltmanns·2024·Clinical Psychological Science
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  • Speech Perception in Noise and Cognitive Skills in Children With Varying Degrees of Music Training

    Purpose:This registered report aimed to replicate previous findings showing that years of music training predicts speech-perception-in-noise (SPIN) skills in children. In addition, it aimed to investigate whether the musician SPIN advantage is influenced by cognitive factors such as general intelligence or working memory.Method:Following planned sample size estimations and analyses, 62 school-age children with varying degrees of music training participated in the study. Children's general intelligence quotients, working memory, and SPIN skills were assessed during one visit to our laboratory. We implemented hierarchical multiple regression analyses to examine the study aims.Results:Our regression analyses indicated that years of instrument training did not significantly account for variance in SPIN skills. The explanatory power of our model was enhanced only when working memory, particularly auditory working memory, was included as a predictor. Auditory working memory was associated with both SPIN skills and years of instrument training.Conclusions:Our study was unable to replicate previous findings that linked years of instrument training to SPIN skills in childhood. This suggests caution regarding prior claims that music training can be used with children to optimize learning in noisy environments. However, we did find evidence that musicianship is associated with enhanced auditory working memory skills, which could have positive implications for children's lifelong outcomes.Supplemental Material:https://doi-org.proxy.lib.duke.edu/10.23641/asha.28373786

    Kaylee Castleberry, Alexandra Amato, Carlos R. Benítez-Barrera·2025·Journal of Speech, Language, and Hearing Research
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  • Hostile and prosocial reactions to Christian privilege in the United States: A registered report

    Reactions to privilege include hostility (e.g., denial of privilege) and prosociality (e.g., remorse). Studies suggest that White Americans often react hostilely when confronted with racial and class privilege, but research on reactions to religious privilege is limited. The current registered report investigated how religiousness is related to hostile and prosocial reactions to religious privilege. Three studies tested the relationship between religiousness and reactions to religious privilege. In Study 1, a correlational study, we expected parochial religious variables (Christian nationalism, religious fundamentalism, perceptions of religious threat) would be related to hostile reactions to religious privilege, whereas more universal dimensions of religiousness (intellectual humility, gratitude toward God, and sanctification of social justice) would be related to prosocial reactions. Study 2 induced actual reactions to being confronted with religious privilege, manipulating whether privilege was framed as a merit-based or a group-based threat. Study 3 primed universal and parochial religiousness to examine the causal relationship between religiousness and reactions to privilege. Across our studies (Study 1 N = 395, Study 2 N = 737, Study 3 N = 699), parochial religiousness was related to hostile reactions, whereas two forms of universal religiousness (religious intellectual humility, sanctification of social justice) were related to prosocial reactions. Merit-based information about religious privilege decreased denial, whereas a religious humility intervention increased denial. Further research is needed on interventions to increase prosocial responses. (PsycInfo Database Record (c) 2024 APA, all rights reserved)

    Monica Weedman, Rosemary L. Al-Kire, Jo-Ann Tsang·2024·Psychology of Religion and Spirituality
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  • Self-esteem, relationship threat, and dependency regulation: Independent replication of Murray, Rose, Bellavia, Holmes, and Kusche (2002) Study 3

    Across three studies, Murray, Rose, Bellavia, Holmes, and Kusche (2002) found that low self-esteem individuals responded in a negative manner compared to those high in self-esteem in the face of relationship threat, perceiving their partners and relationships less positively. This was the first empirical support for the hypothesized dynamics of a dependency regulation perspective, and has had a significant impact on the field of relationship science. In the present research, we sought to reproduce the methods and procedures of Study 3 of Murray et al. (2002) to further test the two-way interaction between individual differences in self-esteem and situational relationship threat. Manipulation check effects replicated the original study, but no interaction between self-esteem and experimental condition was observed for any primary study outcomes.

    Lorne Campbell, Rhonda N. Balzarini, Taylor Kohut, Kiersten Dobson, Christian M. Hahn, Sarah E. Moroz, Sarah C. E. Stanton·2018·Journal of Research in Personality
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  • A closer look at the size of the gaze-liking effect: a preregistered replication

    This study is a direct replication of gaze-liking effect using the same design, stimuli and procedure. The gaze-liking effect describes the tendency for people to rate objects as more likeable when they have recently seen a person repeatedly gaze toward rather than away from the object. However, as subsequent studies show considerable variability in the size of this effect, we sampled a larger number of participants (N = 98) than the original study (N = 24) to gain a more precise estimate of the gaze-liking effect size. Our results indicate a much smaller standardised effect size (dz = 0.02) than that of the original study (dz = 0.94). Our smaller effect size was not due to general insensitivity to eye-gaze effects because the same sample showed a clear (dz = 1.09) gaze-cuing effect – faster reaction times when eyes looked toward vs away from target objects. We discuss the implications of our findings for future studies wishing to study the gaze-liking effect.

    Jason Tipples, Anna and Pecchinenda·2019·Cognition and Emotion
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  • Administration of galacto-oligosaccharide prebiotics in the Flinders Sensitive Line animal model of depression

    Alexandra Bannach-Brown, Sandra Tillmann, Malcolm Robert MacLeod, Gregers Wegener·2019·BMJ Open Science
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  • Are consumption taxes really disliked more than equivalent costs? Inconclusive results in the USA and no effect in the UK

    In two experiments on hypothetical purchase decisions, Sussman and Olivola (2011) found that US citizens prefer avoiding tax-related costs over avoiding tax-unrelated monetary costs of the same size. The original Experiment 1 and 2 tests of this Tax Aversion indicated that people are willing to wait longer to receive a discount when it refers to taxes (e.g., “axe-the-tax discount”) than when it is just a regular discount (e.g., “customer rewards”). We conducted high-powered close replications of both original studies, Experiment 1 (N = 590) and Experiment 2 (N = 650), which reveal either no effect (Experiment 1: r = 0.02, 95% CI [−0.06, 0.10]) or a small effect (Experimental 2: r = 0.09, 95% CI [0.01, 0.16]) in the USA. We also replicated both experimental procedures in the UK to test whether the effect generalized to a value added tax system. Neither Experiment 1 (N = 595; r = 0.01, 95% CI [−0.07, 0.09]) nor Experiment 2 (N = 673; r = 0.03, 95% CI [−0.04, 0.11]) revealed an effect in the UK. Tax Aversion in hypothetical consumption decisions seems to be a smaller phenomenon than originally proposed and does not generalize to a value added tax system.

    Jerome Olsen, Christoph Kogler, Mark J. Brandt, Linda Dezső, Erich Kirchler·2019·Journal of Economic Psychology
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