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The NUDGE trial pragmatic trial to enhance cardiovascular medication adherence: study protocol for a randomized controlled trial

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AuthorsRussell E. GlasgowChristopher E. KnoepkeDavid MagidGary K. GrunwaldThomas J. GloriosoJoy WaughtalJoel C. MarrsSheana BullP. Michael Ho
Year2021
VenueTrials
Item typeJournal Article

Nearly half of patients do not take their cardiovascular medications as prescribed, resulting in increased morbidity, mortality, and healthcare costs. Mobile and digital technologies for health promotion and disease self-management offer an opportunity to adapt behavioral “nudges” using ubiquitous mobile phone technology to facilitate medication adherence. The Nudge pragmatic clinical trial uses population-level pharmacy data to deliver nudges via mobile phone text messaging and an artificial intelligent interactive chat bot with the goal of improving medication adherence and patient outcomes in three integrated healthcare delivery systems.

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JMIRJMIR: Stage 2 OnlyStage 1 ManuscriptTrials

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AuthorsRowan Shore-PlavecRachel ZuckerThomas J. GloriosoSheana BullLarry A. AllenJoseph J. SaseenKaty E. TrinkleyPamela PetersonJoy WaughtalP. Michael Ho
Year2025
VenueJournal of Medical Internet Research
Item typeJournal Article

We conducted this secondary analysis to assess whether greater engagement with a text messaging intervention was associated with improved cardiovascular medication adherence at 12-months.

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JMIRJMIR: RegisteredJMIR: Stage 2 OnlyStage 1 LinkedStage 2 Manuscript