INTRODUCTION: Different biologically active products have been applied to manage pain and mandibular functional disability in intra-articular Temporomandibular Joint Disorders (TMD) but without effectively controlling the degenerative joint disease. Platelet concentrates aim to enhance tissue healing and facilitate its regeneration. Intra-articular injections of liquid Platelet-Rich Fibrin (PRF) in patients with TMD have demonstrated effectiveness in the management of pain and dysfunction, also having a stimulatory effect on cartilage and bone tissuOeBs.JECTIVE: This review aims to examine how research has been conducted regarding the use of PRF as a treatment tool for Temporomandibular Joint Disorders (TMD). INCLUSION CRITERIA: This review will focus on studies that address adults with TMD without restrictions on gender or ethnicity. TMD will be classified according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) physical axis (Axis I). Also, we will include publications in any language or date of publication. METHODS: This protocol will follow the JBI guidance for Scoping Reviews. We shall conduct a literature search to identify published research, with no limits on the year of publication/conception, format, or language. Two independent reviewers will screen and select publications based on inclusion criteria. The review decision process will be provided in a flowchart-based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations for Scoping Reviews. Finally, we shall present extracted data from each study in piloted forms in conceptual categories such as intervention type, population and sample size, duration of intervention, aims, the methodology adopted, key findings, and gaps in the research.